Great, but needs sound work.
That was long. I didn't expect that. Impressed me a lot that it didn't end after that first short scene. :)
Anyway on with the review!!
Sound - The voice acting is good, however, the quality of the voices is bad in the sense that it makes everyone sound like they have a lisp. Try getting some better sound software and take more time on it making it perfect (especially if you plan on making this a series).
Animation - The characters were very original, unique, and... well.. cool. But! I think you tried to be lazy and not add very many action sequences. That or you aren't good at drawing action poses. Probably the latter judging by how the girl ran. If you are gonna focus on her running for so long, at least add a few more frames to the animation.
Animation Tip - If you can't draw action poses well, have a friend take pictures of you in different poses, then trace a few in-betweens, you'll get the hang of it pretty quick that way.
Music - Best music arranging I've heard in a Flash... ever. Better than a lot of shows on TV too. Very very well done. The extra loading time was definitely worth it.
Overall - Fucking loved it. Very posh. :o